The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients

The Effect of Antiretroviral Combination Treatment on Epstein-Barr Virus (EBV) Genome Load in HIV-Infected Patients

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We evaluated the effect of combination anti-retroviral treatment (cART) on the host control of EBV infection in moderately immunosuppressed HIV-1 patients.Twenty HIV-1 infected individuals were followed for five years with repeated read more measurements of EBV DNA load in peripheral blood lymphocytes in relation to HIV-RNA titers and CD4+ cell counts.Individuals with optimal response, i.e.

durable non-detectable HIV-RNA, showed a decline of EBV load to the level of healthy controls.Individuals with non-optimal HIV-1 control did not restore their EBV control.Long-lasting suppression of HIV-replication after early initiation of cART is a biomat for sale prerequisite for re-establishing the immune control of EBV.